ERBB3 OVEREXPRESSION Detail (hg19) (ERBB3)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr12:56,473,645-56,497,289 |
| hg38 | chr12:56,079,861-56,103,505 View the variant detail on this assembly version. |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| cancer | Selumetinib,Afatinib | D |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 24685132 | Detail |
| cancer | Gefitinib,HER2 Inhibitor CP-724,714,Selumetinib | D |
Predictive
|
Supports
|
Resistance |
N/A
|
4 | 24685132 | Detail |
| colorectal cancer | Cetuximab | B |
Predictive
|
Supports
|
Resistance | Somatic | 4 | 25520391 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Preclinical study in KRAS mutant lung and colon cancer models. A synthetic lethal screen using a tot... | CIViC Evidence | Detail |
| Preclinical study in KRAS mutant lung and colon cancer models. A synthetic lethal screen identified ... | CIViC Evidence | Detail |
| High expression of ERBB3 (her3) was associated with shorter overall survival (OS) from Cetuximab tre... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- ERBB3
- Genome
- hg19
- Position
- chr12:56,473,645-56,497,289
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- OVEREXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000267101.3
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/289
Genome browser